Immunoregulatory role of ocular macrophages: the macrophages produce RANTES to suppress experimental autoimmune uveitis.

Autoimmune Uveitis RANTES to Suppress Experimental Macrophages: The Macrophages Produce Immunoregulatory Role of Ocular

Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye.

Intravenously administered mesenchymal stem/stromal cells (MSCs) engraft only transiently in recipients, but confer long-term therapeutic benefits in patients with immune disorders. This suggests that MSCs induce immune tolerance by long-lasting effects on the recipient immune regulatory system. Here, we demonstrate that i.v. infusion of MSCs preconditioned lung monocytes/macrophages toward an ...

Macrophages and Uveitis in Experimental Animal Models

Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal models of uveitis have enabled us to enhance our understanding of the leading role of macrophages in e...

Functional macrophage heterogeneity in a mouse model of autoimmune central nervous system pathology.

Functional macrophage heterogeneity is well appreciated outside the CNS in wound healing and cancer, and was recently also demonstrated in several CNS compartments after "sterile" insults. Yet, such heterogeneity was largely overlooked in the context of inflammatory autoimmune pathology, in which macrophages were mainly associated with disease induction and propagation. In this article, we show...

The retinal pigment epithelial cells modulate phagolysosome activation in macrophages through neuropeptides, a-MSH and NPY

Objective: The main function of the human eye is to detect light, motion, and color from our surroundings. This information is then processed and translated in the brain as vision. However, what is less known about the eye is its ability to regulate immune function. It is this ocular immune privilege that maintains the eye’s ability collect visual information. The degeneration of immune privile...